Hall Lab Publications

2016

Sherrington S.L, Sorsby E., Mahtey, Lenardon M.D., Brown I., Hall R.A. (in preparation). Low mucosal pH facilitates antifungal immunity by de-cloaking the fungal cell wall.

Samantaray S., Correia JN, Garelnabi M, Voelz K, May RC, and Hall RA (2016) Novel cell-based in vitro screen to identify small molecule inhibitors against intracellular replication of Cryptococcus neoformans in macrophages. International Journal of Antimicrobial Agents.

Courjol F, Mille C, Hall RA, Masset A, Aijjou R, Gow NA, Poulain D, Jouault T, Fradin C. (2016). Initiation of phospholipomannan β-1,2 mannosylation involves Bmts with redundant activity, influences its cell wall location and regulates β-glucans homeostasis but is dispensable for Candida albicans systemic infection. Biochimie 120, 96-104.

2015

Courjol F., Jouault T., Mille C., Hall R., Maes E., Sendid B., Mallet JM, Guerardel Y, Gow NA, Poulain D, Fradin C. (2015) β-1,2-Mannosyltransferases 1 and 3 Participate in Yeast and Hyphae O- and N-Linked Mannosylation and Alter Candida albicans Fitness During Infection. Open Forum Infect Dis. 10;2(3):ofv116.

Dixon EF and Hall RA (2015) Noisy neighbourhoods: quorum sensing in fungal-polymicrobial infections. Cell Microbiol. 17, 1431-41.

Hall RA. Dressed to impress: Impact of environmental adaptation on the C. albicans cell wall. (2015), Mol. Microbiol. View article

2013

Hall RA, Gow NA. Mannosylation in Candida albicans: role in cell wall function and immune recognition. (2013), Mol. Microbiol. 90, 1147-1161 View article

Bates S, Hall RA, Cheetham J, Netea MG, MacCallum DM, Brown AJ, Odds FC, Gow NA. Role of the Candida albicans MNN1 gene family in cell wall structure and virulence. (2013), BMC Res Notes, 26, 294 View article

Hall RA, Bates S, Lenardon MD, Maccallum DM, Wagener J, Lowman DW, Kruppa MD, Williams DL, Odds FC, Brown AJ, Gow NA. The Mnn2 mannosyltransferase family modulates mannoprotein fibril length, immune recognition and virulence of Candida albicans. (2013), PLoS Pathog. 9, e1003276 View article

2011

Hall RA, Turner KJ, Chaloupka J, Cottier F, De Sordi L, Sanglard D, Levin LR, Buck J, Mühlschlegel FA. The quorum-sensing molecules farnesol/homoserine lactone and dodecanol operate via distinct modes of action in Candida albicans. (2011), Eukaryotic Cell, 10, 1034-42. View article

Sheth CC, Hall R, Lewis L, Brown AJ, Odds FC, Erwig LP, Gow NA. Glycosylation status of the C. albicans cell wall affects the efficiency of neutrophil phagocytosis and killing but not cytokine signaling. (2011), Med. Mycol., 49, 513-524. View article

Carta F, Innocenti A, Hall RA, Mühlschlegel FA, Scozzafava A, Supuran CT. Carbonic anhydrase inhibitors. Inhibition of the ß-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with branched aliphatic/aromatic carboxylates and their derivatives. (2011), Bioorg. Med. Chem. Lett., 21, 2521-2526 View article

Davis RA, Hofmann A, Osman A, Hall RA, Mühlschlegel FA, Vullo D, Innocenti A, Supuran CT, Poulsen SA. Natural product-based phenols as novel probes for mycobacterial and fungal carbonic anhydrases. (2011), J. Med. Chem. 54, 1682-1692. View article

2010

Hall RA, De Sordi L, Eaton R, Bloor JW, Steegborn C, and Mühlschlegel FA. CO(2) acts as a signalling molecule in populations of the fungal pathogen Candida albicans (2010). PLoS Pathog., 6 :e1001193. View article

Hall RA, Mühlschlegel FA (2010). A multi-protein complex controls cAMP signalling and filamentation in the fungal pathogen Candida albicans. Mol. Microbiol., 75, 579-591. View article

Güzel O, Maresca A, Hall RA, Scozzafava A, Mastrolorenzo A, Mühlschlegel FA, Supuran CT. Carbonic anhydrase inhibitors. The beta-carbonic anhydrases from the fungal pathogens Cryptococcus neoformans and Candida albicans are strongly inhibited by substituted-phenyl-1H-indole-5-sulfonamides. (2010), Bioorg. Med. Chem. Lett., 20, 2508-2511 View article

Innocenti A, Hall RA, Scozzafava A, Mühlschlegel FA, Supuran CT. Carbonic anhydrase activators: activation of the beta-carbonic anhydrases from the pathogenic fungi Candida albicans and Cryptococcus neoformans with amines and amino acids. (2010). Bioorg. Med. Chem., 18, 1034-1037. View article

2009

Fu MS, Hall RA, Mühlschlegel FA. Environmental Stress-Sensing and Pathogenicity in Cryptococcus neoformans. (2009) Pathogenic Yeasts 191-208 View article

Hall RA, Cottier F, Mühlschlegel FA. Molecular networks in the fungal pathogen Candida albicans. (2009), Advances in Applied Microbiology, 67, 191-212 View article

Schlicker C, Hall RA, Vullo D., Middelhaufe S, Gertz M, Supuran CT, Mühlschlegel FA, Steegborn C. Structure and inhibition of the CO2-sensing carbonic anhydrase Can2 from the pathogenic fungus Cryptococcus neoformans. (2009), J. Mol. Biol., 385, 1207-1220 View article

Innocenti A, Hall RA, Schlicker C, Scozzafava A, Steegborn C, Mühlschlegel FA, Supuran CT. Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides. (2009), Bioorg. Med. Chem., 17, 4503-4509. View article

Innocenti A, Hall RA, Schlicker C, Mühlschlegel FA, Supuran CT. Carbonic anhydrase inhibitors. Inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with aliphatic and aromatic carboxylates. (2009), Bioorg. Med. Chem., 17, 2654-2657. View article

Güzel O, Innocenti A, Hall RA, Scozzafava A, Mühlschlegel FA, Supuran CT. Carbonic anhydrase inhibitors. The nematode alpha-carbonic anhydrase of Caenorhabditis elegans CAH-4b is highly inhibited by 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides. (2009), Bioorg. Med. Chem., 17, 3212-3215. View article

Innocenti A, Winum JY, Hall RA, Mühlschlegel FA, Scozzafava A, Supuran CT. Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. (2009), Bioorg. Med. Chem. Lett., 19, 2642-2645. View article

Crocetti L, Maresca A, Temperini C, Hall RA, Scozzafava A, Mühlschlegel FA, Supuran CT. A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases. (2009), Bioorg. Med. Chem. Lett., 19, 1371-1375. View article

2008

Innocenti A, Mühlschlegel FA, Hall RA, Steegborn C, Scozzafava A, Supuran CT. Carbonic anhydrase inhibitors: inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with simple anions. (2008), Bioorg. Med. Chem. Lett., 18, 5066-5070. View article

Hall RA, Vullo D, Innocenti A, Scozzafava A, Supuran CT, Klappa P, Mühlschlegel FA. External pH influences the transcriptional profile of the carbonic anhydrase, CAH-4b in Caenorhabditis elegans. (2008), Mol. Biochem. Parasitol., 161, 140-149. View article