Environmental adaptation of pathogenic fungi
Ruffled colony morphology of Candida albicans
Yeast colony of Candida albicans
Filamentous colony of Candida albicans
Invasion of agar by Candida albicans
Phagocytosis of Candida albicans by macrophages
Phagosome acidification in macrophages
Candida albicans nuclear localisation
Binding of Candida albicans hyphae by bacteria
Candida albicans yeast cells
Phagocytosis of Cryptococcus neoformans
Filamentation on blood agar
Quorum sensing between Candida albicans and bacteria
About Hall Fungal Research
The Hall laboratory was founded in March 2014 through the support of a Career Development Award from the Medical Research Council. The laboratory forms part of the Institute of Microbiology and Infection, which is situated in the School of Biosciences at the University of Birmingham.
We are interested in investigating the interactions that occur between the innate immune cells of our bodies and invading microbes during infection, with a specific focus on fungal disease.
Why study fungi?
Recent estimates suggest that each year just over 2,000,000 individuals suffer from a life-threatening fungal disease. In addition to this, many people suffer with superficial fungal infections including athlete's foot, dandruff and thrush. Therefore, fungi are a major contributor to human mortality and morbidity. Despite this, our knowledge of fungal disease mechanisms are in their infancy compared to that of most bacterial infections.
Our favourite fungi
The fungal kingdom is estimated to contain up to 5 million species, but currently only 100,000 have been described. Fungi have been identified in diverse environments including the human body, soil and deep-sea sediments. Not all fungi are pathogenic. In fact, many fungi that can cause disease are classed as opportunistic pathogens as they mainly cause disease in individuals that have a weakened immune system (i.e. HIV, cancer and trauma patients and the elderly). We are mainly interested in Candida albicans and Candida glabrata, which are opportunistic fungal pathogens of humans, causing superficial skin infections (i.e. thrush) and fatal systemic disease. We also dabble with Cryptococcus neoformans (another fungal pathogen) and some bacteria.
Annual BSMM Conference
The annual BSMM conference will be held in Birmingham on the 19th - 21st March. bsmm.org/conferences
HFP meeting 13th - 19th May
Don't forget to register for the HFP meeting that is held in Nice 13th - 19th May
UK Fungus Day
UK fungus day will be held on the 8th October 2017. Start planning your event now ukfungusday.co.uk/
Welcome to Xiangni Lu
Welcome to Xiangni Lu, a self funded PhD student that who will work with fungal quorum sensing molecules.
Welcome to Pizga Kumwenda
Welcome to Pizga Kumwenda the newest member of the Hall Lab. Pizga is a WTSA funded PhD student who will expose how the host environment regulates the host-pathogen interaction, through modulation of the fungal cell wall.
PHD Positions Available
If you are interested in host-pathogen interactions or poly microbial interaction then get in touch and talk to us about our available PhD positions. Polymicrobial interactions or Combinatorial environmental sensing