Environmental adaptation of pathogenic fungi

  • Ruffled colony morphology of Candida albicans

    Ruffled colony morphology of Candida albicans

  • Yeast colony of Candida albicans

    Yeast colony of Candida albicans

  • Filamentous colony of Candida albicans

  • Invasion of agar by Candida albicans

  • Phagocytosis of Candida albicans by macrophages

  • Phagosome acidification in macrophages

  • Candida albicans nuclear localisation

  • Binding of Candida albicans hyphae by bacteria

  • Candida albicans yeast cells

  • Phagocytosis of Cryptococcus neoformans

  • Filamentation on blood agar

  • Quorum sensing between Candida albicans and bacteria

About Hall Fungal Research

The Hall laboratory was founded in March 2014 through the support of a Career Development Award from the Medical Research Council. The laboratory forms part of the Institute of Microbiology and Infection, which is situated in the School of Biosciences at the University of Birmingham.

We are interested in investigating the interactions that occur between the innate immune cells of our bodies and invading microbes during infection, with a specific focus on fungal disease.

Why study fungi?

Recent estimates suggest that each year just over 2,000,000 individuals suffer from a life-threatening fungal disease. In addition to this, many people suffer with superficial fungal infections including athlete's foot, dandruff and thrush. Therefore, fungi are a major contributor to human mortality and morbidity. Despite this, our knowledge of fungal disease mechanisms are in their infancy compared to that of most bacterial infections.

Our favourite fungi

The fungal kingdom is estimated to contain up to 5 million species, but currently only 100,000 have been described. Fungi have been identified in diverse environments including the human body, soil and deep-sea sediments. Not all fungi are pathogenic. In fact, many fungi that can cause disease are classed as opportunistic pathogens as they mainly cause disease in individuals that have a weakened immune system (i.e. HIV, cancer and trauma patients and the elderly). We are mainly interested in Candida albicans and Candida glabrata, which are opportunistic fungal pathogens of humans, causing superficial skin infections (i.e. thrush) and fatal systemic disease. We also dabble with Cryptococcus neoformans (another fungal pathogen) and some bacteria.

Latest News

  • PHD Positions Available

    If you are interested in host-pathogen interactions or poly microbial interaction then get in touch and talk to us about our available PhD positions. Polymicrobial interactions or Combinatorial environmental sensing

  • PHD position available.

    If you are interested in combining wet lab research with computational biology to address how an important fungal pathogen adapts to the environment in our bodies then check out our advertised PhD position on findaphd.com

  • Polymicrobial interaction meeting

    Our first polymicrobial interaction meeting will be held on the 9th January 2015 in Birmingham. Program, time and location will be announced shortly.

  • BSMM 2015

    The 2015 BSMM conference will be held in Aberdeen. Don't forget to register and submit an Abstract

  • First Hall Lab PhD studentship awarded

    Emily Dixon has been awarded an MRC funded PhD studentship to work in the Hall Lab from September 2014. Emily will be the first PhD student of the Hall Lab, and will be jointly supervised by Robin May.

  • Announcement of a new antifungal book

    Harizonpress announce the release of a new book on antifungals entitled Antifungals: From Genomics to Resistance and the Development of Novel Agents. For more information visit http://www.horizonpress.com/antifungals

  • Consortium for polymicrobial interactions

    Steve Diggle (Nottingham University) and Rebecca Hall (University of Birmingham) have been awarded funding, through a Birmingham-Nottingham Strategic Fund, to establish a mini consortium on polymicrobial interactions. Anyone interested in getting involved should contact Steve or Rebecca.